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CAS NO.595-40-4
Product Name:L-Isovaline
Synonym:L(+)-Isovaline monohydrate;(2S)-2-amino-2-methylbutanoic acid;L-iso-valine
Cas No:595-40-4
Molecular Formula:C5H11NO2
Molecular Weight:117.15
Appearance:White to off-white powder/solid
Purity(1H NMR):99%min
EE:99%min
Brief introduction:Isovaline is a rare amino acid transported to earth by the Murchison meteorite, which landed in Australia in 1969. The discovery of isovaline in the biosphere demonstrates an extraterrestrial origin of amino acids and has been linked to the homochirality of life on earth suggesting a role in the origin of life.
The structure of isovaline is similar to the amino acids GABA and glycine, the chief inhibitory neurotransmitters in the mammalian central nervous system. Isovaline acts as an analgesic in mice by activating peripheral GABAB receptors. In a mouse model of osteoarthritis isovaline restored mobility, suggesting inhibition of nociception by isovaline in the synovial membrane of the mouse knee.
Isovaline does not cross the blood-brain barrier and does not enter into the brain or spinal cord. Drugs such as opioids cross the blood-brain barrier to produce analgesia but often produce confusion, sedation and addiction.
Isovaline acts downstream to the cyclooxygenase system that NSAIDs inhibit, suggesting a means to avoid adverse effects such as irritation of the gastrointestinal system.
This novel first-in-class compound has potential for treatment of acute and chronic pain, without the negative side effects associated with other commonly used analgesics.
ZER Chem is an internationally well-recognized peptide reagent, custom peptide and antibody manufacturing company.We are able to give rapid response to the international market demand, providing high quality, value-added and high-tech peptide related products,reliying on a number of outstanding technical backbone, years excellent management experience and economy of scale.
At present, the company has more than 300 production technologies of protection amino acid and non natural amino acid series products and can carry out industrial production, so as to provide you with high-quality and high-quality products at any time. We always adhere to the supremacy of users, serve customers attentively, and use our own services to impress customers. We believe that in the future, we will be able to become your reliable partner