Keywords

• Irinotecan Hydrochloride china supplier
• Camptothecin II
• CPT-II

Quick Details

• ProName: Irinotecan Hydrochloride china manufac...
• CasNo: 100286-90-6
• Molecular Formula: C33H39ClN4O6
• Appearance: White powder
• Application: API
• DeliveryTime: Depend on the quantity client want
• PackAge: According to client's requirements
• Port: SHANGHAI,CHINA
• ProductionCapacity: 10 Metric Ton/Month
• Purity: 99.0%
• Storage: Keep under the shady and cool place an...
• Transportation: By sea/by air/by express
• LimitNum: 1 Kilogram

Superiority

Hangzhou ZeErRui Chemical Co., Ltd. is a leading company that is focused on developing and producing high-quality flavor ingredients used for foods, pharmaceutic, cosmetics, and daily-use goods. Our goal is to produce flavor ingredients through sciences and further to provide our flavor ingredients to products that can delight human life quality.

ZER Chem has capacity to supply more than 200 high-quality flavor ingredients to our customers. Our R&D team works tirelessly and innovatively to develop and customize flavor ingredients to satisfy the needs of our customers. We look forward to collaborating with our customers to bring the best flavor ingredients to the world.

Details

Product name:Irinotecan hydrochloride

Synonyms:CamptothecinII;CPT-II;[1,4′-Bipiperidine]-1′-carboxylicacid,CPT-11,(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-ylester;(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl[1,4'-bipiperidine]-1'-carboxylicacidesterhydrochloride;(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-ylester

CAS No:3100286-90-6

Molecular formula:C33H39ClN4O6

Molecular Weight:623.15

Appearance:Pale yellow powder

Melting point 250-256°C (dec.)

Storage conditions Refrigerator

Iritecan hydrochloride is a semi synthetic derivative of water-soluble camptothecin. It is light yellow powder or light yellow crystalline powder at room temperature, and it has no odor. It is slightly soluble in water, ethanol or chloroform and insoluble in acetone. Camptothecin can be specifically combined with topoisomerase I, which induces reversible single strand breaks, which leads to the spin of DNA double strand structure; Iritecan and its active metabolite SN-38 can be combined with topoisomerase I-DNA complex, thus preventing the reconnection of single bond, thus producing cytotoxicity. This chemicalbook cytotoxicity is time dependent, and has a specific effect on phase s, and is more toxic than iritecan. It is suitable for the treatment of advanced colorectal cancer patients, combined with 5-fluorouracil and folic acid in the treatment of patients with advanced colorectal cancer who have not received chemotherapy before. As a single drug, the treatment of patients who have failed to be treated by chemotherapy with 5-fluorouracil is used. Iritecan has a wide spectrum and strong antitumor activity in vivo and in vitro research. It is important that iritecan and its metabolites are still effective for the tumor expressing multidrug resistance.