Keywords

• Dacomitinib (PF299804) china supplier
• PF-00299804
• DacoMitinib

Quick Details

• ProName: Dacomitinib (PF299804) china manufactu...
• CasNo: 1110813-31-4
• Molecular Formula: C24H25ClFN5O2
• Appearance: white solid
• Application: Irreversible EGFR tyrosine kinase inhi...
• DeliveryTime: Depend on the quantity client want
• PackAge: According to client's requirements
• Port: SHANGHAI,CHINA
• ProductionCapacity: 100 Kilogram/Month
• Purity: 99%
• Storage: room temperature
• Transportation: According to client's requirements
• LimitNum: 10 Gram

Superiority

Dacomitinib (pf299804, pf299) is an effective and irreversible pan erbB inhibitor. It acts most effectively on EGFR. The IC50 in cell-free test is 6nm. Dacomitinib inhibited erbB2 and ErbB4, and the corresponding IC50 values were 45.7 nm and 73.7 nm, respectively. Dacomitinib can efficiently act on NSCLC carrying EGFR or erbB2 mutant (gefitinib resistant) and egfrt790m mutant. Dacomitinib can inhibit cell growth and induce apoptosis.

Boiling point   665.7±55.0 °C(Predicted)

Density   one point three four four

Form white solid

Acidity coefficient (PKA) 12.05 ± 0.43 (predicted)

Details

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barriers, high value-added, low pollution characteristics of the project, landing the project of innovative non patented route design, difficult process development and rapid industrialization.  Starting from the advantages of combining technology research and stable production, we cooperated with domestic and foreign large pharmaceutical companies in the development of generic drugs and innovative drugs.

It also has hardware facilities and support teams that match the strength of R & D and production: With LCMS, HPLC and other perfect detection means, professional testing team and perfect quality control system; With a pilot base, a stable GMP standard production capacity, and a new GMP workshop is building; With regular financial, legal ERP system and professional sales and logistics team.