Pamoic Acid manufacture CAS NO.130-85-8

Product name: Pamoic Acid

Synonyms:4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid);1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid)；2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-；embonic acid

CAS No:130-85-8

Molecular formula:C23H16O6

Molecular Weight:388.37

Appearance:Yellow powders

Purity（HPLC）≥99.0%

Assays（HPLC）:98~102%

Any individual impurity≤0.5%

Waters≤0.5%

Residue on ignition≤0.5%

Heavy Metals≤20ppm

Loss on drying≤0.5%

Brief introduction:Pamoic acid, also called embonic acid, is a naphthoic acid derivative. Salts and esters of pamoic acid are known as pamoates or embonates. It can be prepared by the reaction of 2-hydroxy-3-naphthoic acid with formaldehyde.
In pharmacology, the salt form of pamoic acid (pamoate ion) can be used as a counter ion of a drug compound to increase the solubility of the drug in water. The presence of multiple oxygen atoms enables significant hydrogen bonding to occur. Hydrogen bonds facilitate the dissolution of compounds in water.
Pamoic acid has agonist activity for the orphan G protein-coupled receptor GPR35 by which it activates ERK and beta-arrestin2, and causes antinociceptive activity. Although (like other drug salts) it has been considered an inactive compound by the FDA, these recent data suggest that its permitted uses may need to be reexamined.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas,  is a high-tech enterprise integrating R&D, production and sales. The company has established long-term cooperation with famous pharmaceutical and chemical enterprises, scientific research institutions and university laboratories at home and abroad. It is committed to chemical customization synthesis, high value-added pharmaceutical intermediates and new drug research and development. For the customized production of gram, kilogram and industrial ton grade products for laboratory research. At the same time, our company serves research institutes and universities, provides active compounds for scientific research, chemical reagents, and accepts customized synthesis.

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